Individual and combined effects of mirex and polychlorinated biphenyls on mouse liver-cells
Abraham, R; Koepke, UC; Goldberg, L; Coulston, F
HERO ID
2151151
Reference Type
Journal Article
Subtype
Abstract
Year
1974
Language
English
| HERO ID | 2151151 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 1974 |
| Title | Individual and combined effects of mirex and polychlorinated biphenyls on mouse liver-cells |
| Authors | Abraham, R; Koepke, UC; Goldberg, L; Coulston, F |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 29 |
| Issue | 1 |
| Page Numbers | 128-129 |
| Abstract | Liver enlargement, proliferation of smooth endoplasmic reticulum and increases in microsomal enzymes are common hepatic responses of rodents to the administration of single polychlorinated compounds, but little is known regarding the combined effects of 2 such compounds. A study was therefore undertaken of a mixture of polychlorinated biphenyls (PCB) (Aroclor 1254) and Mirex in Charles River CD-1 mice. The compounds were administered in the diet at the following levels for 7 days: group I, chow; group II, PCB 500 ppm; group III, Mirex 90 ppm; and group IV, Mirex 90 ppm and PCB 500 ppm. Loss of body weight, increases in liver weight and demethylase activity were recorded in all 3 experimental groups, being most pronounced in group IV. Glucose 6-phosphatase activity was decreased in groups II and III and remained unchanged in group IV. In mice of group IV there were striking structural changes in hepatic lysosomes, with formulation of large myeloid bodies (lysosomes containing cellular debris) and numerous autophagic vacuoles that were PAS-positive and stained for acid phosphatase. These changes were reflected in the elevated activities of both total and sedimentable acid phosphatase. The lysosomes were normal in all other groups. Further changes included loss of glycogen in groups III and IV and hepatic cell necrosis in group IV. The capacity of the combination of toxicants to elicit unique lysosomal responses posed questions regarding the biological interaction between environmental chemicals. (Author abstract by permission) (Abstract No. 135) |
| Wosid | WOS:A1974T653800141 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Washington, D.C. |
| Conference Name | Thirteenth Annual Meeting of the Society of Toxicology |
| Conference Date | March 10-14, 1974 |
| Is Public | Yes |
| Language Text | English |
| Is Peer Review | No |
| Relationship(s) |
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