Persistence of PCB homologs and isomers in domestic hen and rat
Baker, FD; Bush, B; TUMASONI.C
HERO ID
2152979
Reference Type
Journal Article
Subtype
Abstract
Year
1974
Language
English
| HERO ID | 2152979 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 1974 |
| Title | Persistence of PCB homologs and isomers in domestic hen and rat |
| Authors | Baker, FD; Bush, B; TUMASONI.C |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 29 |
| Issue | 1 |
| Page Numbers | 104-105 |
| Abstract | This study was undertaken to (1) separate, identify, and quantitate the 18 major component of Aroclor 1254 in adult hens and pregnant rats, in the embryos and fetuses, and in the progeny of both species during and after exposure; (2) compare the metabolic patterns of Aroclor 1254 for both species; (3) correlate toxicity and abnormalities with specific isomers; and (4) examine the possible relationship between induced mixed-function oxidase activity and hydroxylation of isomers. Aroclor 1254, emulsified in drinking water, was administered at a level of 6 mg/kg body weight (50 ppm) to hens and to rats over periods of 6 and 9 weeks respectively. After the intake was terminated, the populations were observed for 20 and 13 weeks respectively as the level of PCB declined. Egg yolks, tissues of viable 18-day-old embryos, and surviving 5-day-old chicks were analyzed by thin-layer chromatography and by gas chromatography during the course of the experiment. Data suggest that 4-4’chlorination is more important than degree of chlorination in determining persistence of chlorinated biphenyl in the hen, chick embryo and hatched chick. Results with both hens and rats indicate that fertility was not affected at the level of PCB employed and that the degree, and termination, of embryonic and/or fetal development was related directly to length of exposure. Mixed-function oxidase activity (MFO) on liver microsomal preparations from rat mothers, fetuses and pups was measured by determination of liver microsomal cytochrome P-450 and aniline hydroxylase levels. Preliminary results indicate sex-related MFO response. |
| Wosid | WOS:A1974T653800081 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Washington, D.C. |
| Conference Name | Thirteenth Annual Meeting of the Society of Toxicology |
| Conference Date | March 10–14, 1974 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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