Computer-assisted reduction and display of gas-chromatographic data from long-term toxicity studies of commercial mixtures of polychlorinated biphenyls in chickens and in rats
Bush, B; Lo, FC; Baker, FD
HERO ID
2155948
Reference Type
Journal Article
Subtype
Abstract
Year
1974
Language
English
| HERO ID | 2155948 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 1974 |
| Title | Computer-assisted reduction and display of gas-chromatographic data from long-term toxicity studies of commercial mixtures of polychlorinated biphenyls in chickens and in rats |
| Authors | Bush, B; Lo, FC; Baker, FD |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 29 |
| Issue | 1 |
| Page Numbers | 105 |
| Abstract | Homologs and isomers of PCB represented by 18 gas chlomatographic zones have been traced through the tissues of adult animals to their young in long-term studies of the chicken and the rat. Three or more tissue types from each animal sacrificed have been analyzed and in order to facilitate the chemical analysis and to reduce the mass of data produced, several novel techniques have been developed and will be described. The Hewlett-Packard 7600A system was employed. In the chicken experiment, integrator output was converted into logarithmic bar charts to give a visual display of relative changes in concentration during residence in the animals, using a Wang Programming Calculator and Data Plotter. Conclusions were drawn from the data, in spite of the large disparities observed between individuals, by determining frequencies of occurrence above and below datum lines drawn across the bar charts. In the rat experiment, Fortran programs were written to display the data as linear or logarithmic bar charts, tabulate nominal concentrations of each chromatographic zone, plot the variation of each zone concentration with time for each tissue type in the adult, fetus and pup throughout the experiment. Detailed observations and conclusions will be described in an accompanying presentation. |
| Wosid | WOS:A1974T653800082 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Washington, D.C. |
| Conference Name | Thirteenth Annual Meeting of the Society of Toxicology |
| Conference Date | March 10–14, 1974 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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