Distribution and kinetics of 2,4,5,2,'5'-pentachlorobiphenyl (PCB) in male rat
Matthews, HB; Bend, , JR; Anderson, MW
HERO ID
2175707
Reference Type
Journal Article
Subtype
Abstract
Year
1974
Language
English
| HERO ID | 2175707 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 1974 |
| Title | Distribution and kinetics of 2,4,5,2,'5'-pentachlorobiphenyl (PCB) in male rat |
| Authors | Matthews, HB; Bend, , JR; Anderson, MW |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 29 |
| Issue | 1 |
| Page Numbers | 88 |
| Abstract | The distribution of [14C]PCB in male rats was studied at times from 5 min to 7 days after iv doses of 0.06, 0.6 and 6.0 mg/kg. The PCB was rapidly cleared from blood with liver and lean tissues being major depots at early times (<1 hr). At 5 min post dose, hepatic uptake accounted for up to 35% of the total administered radioactivity. The compound is metabolized in the liver and excreted into the bile. At all times, only parent PCB was found in blood tissues. There was a biphasic decay with time for both blood and liver concentrations of PCB. Ratios of liver-to-blood concentrations of PCB decreased from 10 at early times to a steady-state value of 3 at 12 hr. Lean tissue-to-blood concentration ratios remained near unity during the study period; however, due to its mass, lean tissue served as a major storage site for PCB at early times. Fat-to-blood ratios rose steadily over the 7-day period and fat became the major depot at later times. Fat levels of PCB were as high as 46% of the total dose and were still 19% at 7 days. After 8 hr, about 80% of unexcreted PCB was in the fat. There was no evidence for saturation of storage or excretion sites as up to a 100-fold increase in dose had little effect on relative distribution of PCB. Pre-treatment of rats with an inducer (phenobarbital) or an inhibitor (SKF-525A) of hepatic microsomal enzymes had marked effects on the distribution pattern of PCB in all tissues 24 hr after dosing, particularly, in the fat. The results indicate that liver and lean tissue are the major sites of PCB clearance from blood at early times after dosing and storage in fat is the major determinant of PCB persistence in the body. |
| Wosid | WOS:A1974T653800039 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Washington, D.C. |
| Conference Name | Thirteenth Annual Meeting of the Society of Toxicology |
| Conference Date | March 10–14, 1974 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |