Influence of a polychlorinated biphenol (PCB) on biochemical effects and metabolism of aflatoxin
Peters, EL; Friedman, L; Davis, KG
HERO ID
2180888
Reference Type
Journal Article
Subtype
Abstract
Year
1974
Language
English
| HERO ID | 2180888 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 1974 |
| Title | Influence of a polychlorinated biphenol (PCB) on biochemical effects and metabolism of aflatoxin |
| Authors | Peters, EL; Friedman, L; Davis, KG |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 29 |
| Issue | 1 |
| Page Numbers | 94 |
| Abstract | PCB, a known stimulator of microsomal enzyme activity (Toxicol. Appl. Pharmacol. 23, 112, 1972), was examined for its effects on the in vivo and in vitro inhibition ofliver RNA1 synthesis by aflatoxin B1 (B1). The in vitro metabolism of B1 by liver preparations from control and PCB-fed rats was also examined. Aroclor 1254 was fed in the diet at 25 and 100 ppm to male and female Osborne-Mendel adult rats for 60 days. This treatment produced liver enlargement and fatty liver but little or no increase in plasma SGOT or SGPT. In control rats, B1 (0.50 mg/kg) inhibited incorporation of [14C) orotic acid into liver RNA by 30.8 and 65.3% in females and males, respectively. However, inhibition was reduced to 0.0 and 27.3% in female and male rats fed 25 ppm PCB. Dietary PCB also abolished the 27.3% inhibition of protein synthesis produced by B1 in male rats. Both levels of PCB stimulated the conversion of B1 to aflatoxin M1 by approximately 50-fold (while stimulating the metabolism of aminopyrine by only 2- to 3-fold). Inhibition of RNA synthesis in liver slices exposed to B1 in vitro was also reduced by a similar PCB treatment but to a much smaller degree (65.6 vs 50.0%). Apparently, dietary PCB treatment of rats stimulated the conversion of B1 to inactive or less active metabolites. |
| Wosid | WOS:A1974T653800055 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Washington, D.C. |
| Conference Name | Thirteenth Annual Meeting of the Society of Toxicology |
| Conference Date | March 10–14, 1974 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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