Toxicodynamics of PCB 1254 in the beagle dog and miniature swine
Couvillion, JL; Earl, FL; Van Loon, EJ
HERO ID
2204047
Reference Type
Journal Article
Year
1974
Language
English
| HERO ID | 2204047 |
|---|---|
| In Press | No |
| Year | 1974 |
| Title | Toxicodynamics of PCB 1254 in the beagle dog and miniature swine |
| Authors | Couvillion, JL; Earl, FL; Van Loon, EJ |
| Volume | 29 |
| Issue | 1 |
| Page Numbers | 104 |
| Abstract | Abstract #73: Reproductive effects of Aroclor 1254 were studied in the Beagle dog and miniature swine at daily oral doses of 0.25,l and 5 mg/kg in the dog and 1,lO and 30 mg/kg in the pig. An anorectic response was induced in the dog at the 5 mg/kg dose while a higher dose of 30 mg/kg was required for the pig. In both species fetal liver concentrations and fetal abnormalities showed that PCB penetrated the placental barrier. The rate of decay of PCB concentration in blood was measured in the adult Beagle dog. After 3 weeks of conditioning at 10 mg/kg, po, dogs were infused iv with 50 mg/kg Aroclor 1254 as a 10 y0 emulsion. A half-life of 35 hr was obtained with a first-order decay rate. Tissue analysis for PCB in treated animals showed that adipose tissue and liver were major storage sites. |
| Url | http://www.sciencedirect.com/science/journal/0041008X/29/1 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Washington, DC |
| Conference Name | 13th Annual Meeting of the Society of Toxicology |
| Conference Date | March 10-14, 1974 |
| Comments | Journal: TOXICOL APPL PHARMACOL 29 ISSN: |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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