Population-based mapping of pulmonary adenoma susceptibility 1 locus
Dragani, TA; Hirohashi, S; Juji, T; Kawajiri, K; Kihara, M; Ono-Kihara, M; Manenti, G; Nomoto, T; Sugimura, H; Genka, K; Yokota, J; Takahashi, T; Mitsudomi, T; Nagao, M
HERO ID
2215777
Reference Type
Journal Article
Year
2000
Language
English
PMID
| HERO ID | 2215777 |
|---|---|
| In Press | No |
| Year | 2000 |
| Title | Population-based mapping of pulmonary adenoma susceptibility 1 locus |
| Authors | Dragani, TA; Hirohashi, S; Juji, T; Kawajiri, K; Kihara, M; Ono-Kihara, M; Manenti, G; Nomoto, T; Sugimura, H; Genka, K; Yokota, J; Takahashi, T; Mitsudomi, T; Nagao, M |
| Journal | Cancer Research |
| Volume | 60 |
| Issue | 18 |
| Page Numbers | 5017-5020 |
| Abstract | Pulmonary adenoma susceptibility 1 (Pas1), the major locus affecting inherited predisposition to lung tumor development in mice, maps near the Kras2 gene. We previously reported a significant association between a KRAS2/RsaI polymorphism and the risk and prognosis of lung adenocarcinoma (ADCA) in the Italian population. In the present case-control study, we examined 269 lung ADCA patients, 121 squamous cell lung carcinoma patients, and 632 healthy individuals (general population controls) in the Japanese population with genetic markers spanning approximately 1200 kb in the KRAS2 region. Allele-specific oligonucleotide hybridization revealed the same KRAS2/RsaI polymorphism associated with risk and prognosis as in Italian lung ADCA patients; the polymorphism was significantly associated with clinical stage (P < 0.001) and survival rate (log rank = 0.0014), confirming the mapping of PAS1 and pointing to the role of this locus in human lung cancer. |
| Pmid | 11016621 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |