LOH of chromosome 12p correlates with Kras2 mutation in non-small cell lung cancer
Li, J; Zhang, Z; Dai, Z; Plass, C; Morrison, C; Wang, Y; Wiest, JS; Anderson, MW; You, M
HERO ID
2215779
Reference Type
Journal Article
Year
2003
Language
English
PMID
| HERO ID | 2215779 |
|---|---|
| In Press | No |
| Year | 2003 |
| Title | LOH of chromosome 12p correlates with Kras2 mutation in non-small cell lung cancer |
| Authors | Li, J; Zhang, Z; Dai, Z; Plass, C; Morrison, C; Wang, Y; Wiest, JS; Anderson, MW; You, M |
| Journal | Oncogene |
| Volume | 22 |
| Issue | 8 |
| Page Numbers | 1243-1246 |
| Abstract | Previous observation has shown that the wild-type Kras2 allele is a suppressor of lung cancer in mice. Here we report that loss of heterozygosity (LOH) of chromosome 12p was detected in approximately 50% of human lung adenocarcinomas and large cell carcinomas, and Kras2 mutations were detected at codon 12 in approximately 40% of adenocarcinomas and large cell carcinomas. Interestingly, all of the lung adenocarcinomas and large cell carcinomas containing a Kras2 mutation exhibited allelic loss of the wild-type Kras2 allele when a correlation between LOH of the region on chromosome 12p and Kras2 mutation was made. These results from human lung cancer tissues provide a strong evidence in support of our previous observation in mouse models that the wild-type Kras2 is a tumor suppressor of lung cancer. |
| Doi | 10.1038/sj.onc.1206192 |
| Pmid | 12606951 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |