The genetic basis of susceptibility to lung tumors in mice
Malkinson, AM
HERO ID
2216257
Reference Type
Journal Article
Subtype
Review
Year
1989
Language
English
PMID
| HERO ID | 2216257 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 1989 |
| Title | The genetic basis of susceptibility to lung tumors in mice |
| Authors | Malkinson, AM |
| Journal | Toxicology |
| Volume | 54 |
| Issue | 3 |
| Page Numbers | 241-271 |
| Abstract | This is the first in a series of review articles describing the current state of research on mouse lung tumorigenesis. The system is valuable as a biological model for studying stages of tumor development and the interaction of genetic and environmental factors which dispose towards neoplasia. Additionally, these tumors are analagous to bronchiolo-alveolar cancer in man. Three pulmonary adenoma susceptibility (Pas) genes regulate susceptibility; 1 of these is the proto-oncogene, K-ras2. Candidates for the other 2 genes include the H-2 histocompatibility locus and genes which regulate the basal proliferative rate of the cells from which these tumors arise. Tumor development is favored by a depressed immune system, immature age, and decreased levels of circulating corticosterone. |
| Pmid | 2650016 |
| Wosid | WOS:A1989U115500002 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |