Metabolism of intravenously or orally administered butylene glycol adipic acid polyester
Wright, PL; Levinskas, GJ; Keplinger, ML; Calandra, C
HERO ID
2303761
Reference Type
Journal Article
Subtype
Abstract
Year
1974
Language
English
| HERO ID | 2303761 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 1974 |
| Title | Metabolism of intravenously or orally administered butylene glycol adipic acid polyester |
| Authors | Wright, PL; Levinskas, GJ; Keplinger, ML; Calandra, C |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 29 |
| Issue | 1 |
| Page Numbers | 115 |
| Abstract | Santicizer® 334F is a linear polyester (1700-2200 average molecular weight) composed of alternating units of adipic acid and 1,3-butylene glycol, terminated by a mixture of myristic, palmitic and stearic acids. The metabolism ofSanticizer 334F containing 1 14C-Iabeled adipate was determined following iv or oral administration. The dose was 3 mg/kg or 2.3 μCi/rat. Partition of excreted 14C between carbon dioxide, urine and feces was nearly identical for iv and orally dosed rats. Of the excreted activity, 50.I % appeared as C02 , 28.6% was in urine and 11.2% was in feces. Tissues, excluding the site of injection and liver, contained 2.6% of the oral dose and 4.8% of the iv dose 96 h post-dosing. Livers from the orally dosed animals contained 0.3% and livers of the iv dosed animals contained 4.6% of the respective doses. Extraction and characterization of the 14C-containing residues in the livers demonstrated that the material was not parent Santicizer 334F. Solvent partition and chromatographic behavior suggested that the residual 14C had been incorporated into naturally occurring cellular compounds. These studies demonstrate that this butylene glycol adipic acid polyester underwent hydrolysis when administered either orally or iv. The subsequent metabolic fate was similar following either route of administration. |
| Wosid | WOS:A1974T653800109 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Washington, D.C. |
| Conference Name | Thirteenth Annual Meeting of the Society of Toxicology |
| Conference Date | March 10–14, 1974 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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