Chronic toxicity of methylmercury in adult cat
Charbonneau, SM; Munro, IC; Nera, EA; Armstrong, FAJ; Willes, RF; Grice, HC
HERO ID
2304743
Reference Type
Journal Article
Subtype
Abstract
Year
1974
Language
English
| HERO ID | 2304743 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 1974 |
| Title | Chronic toxicity of methylmercury in adult cat |
| Authors | Charbonneau, SM; Munro, IC; Nera, EA; Armstrong, FAJ; Willes, RF; Grice, HC |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 29 |
| Issue | 1 |
| Page Numbers | 138 |
| Abstract | To obtain data on the effects of long-term consumption of fish containing methylmercury, a chronic toxicity study was undertaken in which adult cats were fed methylmercury-contaminated fish. Doses of 3, 8.4, 20, 46, 74 or 176 μg Hg/kg/day were fed to groups of cats either as methylmercuric chloride or as methylmercury-contarninated fish. Food consumption, weight change, blood mercury concentrations, hematology, urinalysis, serum blood urea nitrogen values and neurological assessment were conducted on all cats. Clinical signs of methylmercury toxicity consisting of ataxia, hypalgesia and loss of balance occurred in cats receiving 176 μg Hg/kg/day after 14 weeks of treatment and in those consuming 74 μg Hg/kg/day after 36 weeks of treatment, at which time the animals were sacrificed. Total mercury and methylmercury concentrations in tissues were correlated with toxic signs, clinical investigations and histopathological findings. |
| Wosid | WOS:A1974T653800167 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Washington, D.C. |
| Conference Name | Thirteenth Annual Meeting of the Society of Toxicology |
| Conference Date | March 10–14, 1974 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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