Metabolism of benzo[a]pyrene in isolated human scalp hair follicles
Vermorken, AJ; Goos, CM; Roelofs, HM; Henderson, PT; Bloemendal, H
HERO ID
2343584
Reference Type
Journal Article
Year
1979
Language
English
PMID
| HERO ID | 2343584 |
|---|---|
| In Press | No |
| Year | 1979 |
| Title | Metabolism of benzo[a]pyrene in isolated human scalp hair follicles |
| Authors | Vermorken, AJ; Goos, CM; Roelofs, HM; Henderson, PT; Bloemendal, H |
| Journal | Toxicology |
| Volume | 14 |
| Issue | 2 |
| Page Numbers | 109-116 |
| Abstract | Human scalp hair follicles contain an enzyme system that metabolizes the carcinogen benzo[a]pyrene. The major ethyl acetate soluble metabolites are 7,8-dihydro-7,8-dihydroxybenzo[a]pyrene,9,10-dihydro-9,10-dihydroxybenzo[a]pyrene and 3-hydroxybenzo[a]pyrene. Addition of 1,1,1-trichloropropene-2,3-oxide (TCPO), an inhibitor of epoxide hydratase, prevents the formation of the dihydrodiols. The overall metabolism can be inhibited by the addition of alpha-naphthoflavone. The metabolism of benzo[a]pyrene in a cell culture of human scalp hair follicles has also been investigated. The results show that the activity of arylhydrocarbon hydroxylase (AHH) and epoxide hydratase (EH) is maintained in culture. |
| Doi | 10.1016/0300-483X(79)90057-X |
| Pmid | 44035 |
| Wosid | WOS:A1979JF36400002 |
| Url | http://www.sciencedirect.com/science/article/pii/0300483X7990057X |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |