Future of early detection of lung cancer: the role of mouse models
Shaw, AT; Kirsch, DG; Jacks, T
HERO ID
2346988
Reference Type
Journal Article
Subtype
Review
Year
2005
Language
English
PMID
| HERO ID | 2346988 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2005 |
| Title | Future of early detection of lung cancer: the role of mouse models |
| Authors | Shaw, AT; Kirsch, DG; Jacks, T |
| Journal | Clinical Cancer Research |
| Volume | 11 |
| Issue | 13 Pt 2 |
| Page Numbers | 4999s-5003s |
| Abstract | Early detection represents one of the most promising approaches to improving lung cancer survival. To date, no screening strategies have been shown to decrease mortality from the disease. Furthermore, no reliable circulating biomarkers of lung cancer have been identified that allow early diagnosis. With the advent of gene targeting technology, new genetically engineered mouse models of lung cancer closely recapitulate the pathobiology of human disease. These mouse models have enabled novel approaches to early detection, including the identification of cancer-associated serum markers using proteomic technologies and the development of new molecular imaging tools. The application of innovative technologies to accurate mouse models promises to accelerate the discovery of new molecular targets and imaging biomarkers for the early detection of lung cancer. |
| Doi | 10.1158/1078-0432.CCR-05-9005 |
| Pmid | 16000603 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |