Amniotic fluid phthalate levels and male fetal gonad function

Jensen, MS; Anand-Ivell, R; Nørgaard-Pedersen, B; Jönsson, BA; Bonde, JP; Hougaard, DM; Cohen, A; Lindh, CH; Ivell, R; Toft, G

HERO ID

2718067

Reference Type

Journal Article

Year

2015

Language

English

PMID

25384265

HERO ID 2718067
In Press No
Year 2015
Title Amniotic fluid phthalate levels and male fetal gonad function
Authors Jensen, MS; Anand-Ivell, R; Nørgaard-Pedersen, B; Jönsson, BA; Bonde, JP; Hougaard, DM; Cohen, A; Lindh, CH; Ivell, R; Toft, G
Journal Epidemiology
Volume 26
Issue 1
Page Numbers 91-99
Abstract <strong>BACKGROUND: </strong>Prenatal exposure to phthalates may pose a threat to human male reproduction. However, additional knowledge about the in vivo effect in humans is needed, and reported associations with genital abnormalities are inconclusive. We aimed to study prenatal di(2-ethylhexyl) phthalate (DEHP) and diisononyl phthalate (DiNP) exposure in relation to cryptorchidism, hypospadias, and human fetal Leydig cell function.<br /><br /><strong>METHODS: </strong>We studied 270 cryptorchidism cases, 75 hypospadias cases, and 300 controls. Second-trimester amniotic fluid samples were available from a Danish pregnancy-screening biobank (n = 25,105) covering 1980-1996. We assayed metabolites of DEHP and DiNP (n = 645) and steroid hormones (n = 545) by mass spectrometry. We assayed insulin-like factor 3 by immunoassay (n = 475) and analyzed data using linear or logistic regression.<br /><br /><strong>RESULTS: </strong>Mono(2-ethyl-5-carboxypentyl) phthalate (5cx-MEPP, DEHP metabolite) was not consistently associated with cryptorchidism or hypospadias. However, we observed an 18% higher (95% confidence interval [CI] = 5%-33%) testosterone level, and a 41% lower (-56% to -21%) insulin-like factor 3 level in the highest 5cx-MEPP tertile compared with the lowest. Mono(4-methyl-7-carboxyheptyl) phthalate (7cx-MMeHP, DiNP metabolite) showed elevated odds ratio point estimates for having cryptorchidism (odds ratio = 1.28 [95% CI = 0.80 to 2.01]) and hypospadias (1.69 [0.78 to 3.67]), but was not consistently associated with the steroid hormones or insulin-like factor 3.<br /><br /><strong>CONCLUSIONS: </strong>Data on the DEHP metabolite indicate possible interference with human male fetal gonadal function. Considering the DiNP metabolite, we cannot exclude (nor statistically confirm) an association with hypospadias and, less strongly, with cryptorchidism.
Doi 10.1097/EDE.0000000000000198
Pmid 25384265
Wosid WOS:000345878000025
Url <Go to ISI>://CCC:000345878000025
Is Certified Translation No
Dupe Override No
Comments Journal: Epidemiology (Cambridge, Mass.) ISSN:
Is Public Yes
Language Text English
Keyword Adult; Amniotic Fluid/chemistry; Case-Control Studies; Cryptorchidism/epidemiology; Denmark/epidemiology; Diethylhexyl Phthalate/analysis; Environmental Exposure/statistics & numerical data; Gonadal Steroid Hormones/analysis; Hydrocortisone/analysis; Hypospadias/epidemiology; Immunoassay; Infant, Newborn; Insulin/analysis; Leydig Cells; Linear Models; Logistic Models; Mass Spectrometry; Phthalic Acids/analysis; Pregnancy; Proteins/analysis; 4010KIX4CK; C42K0PH13C; WI4X0X7BPJ
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