Reproduction and teratology studies with the fungicide ferbam
Minor, JL; Russell, JQ; Lee C-C
HERO ID
2720106
Reference Type
Journal Article
Subtype
Abstract
Year
1974
Language
English
| HERO ID | 2720106 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 1974 |
| Title | Reproduction and teratology studies with the fungicide ferbam |
| Authors | Minor, JL; Russell, JQ; Lee C-C |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 29 |
| Issue | 1 |
| Page Numbers | 120 |
| Abstract | The reproductive and teratogenic effects of the fungicide, ferric dimethyldithiocarbamate (ferbam), were studied in rodents. Daily feeding, equivalent to 23, 66 or 109 mg/kg/day, to male rats for 13 weeks caused deaths and weight loss at the highest dosage without any effect on reproduction. Daily feeding, equivalent to 15 or 51 mg/kg/day, to females for 2 weeks caused a severe weight loss at the high dose and a slight, but not significant, decrease in neonatal survival. Ferbam, administered to rats on days 6-15 of gestation at dosage of 150 mg/kg/ day resulted in some deaths, increased resorption, decreased fetal weight, and caused a slight increase in soft and skeletal tissue anomalies. Ferbam, administered to mice on days 6-14 of gestation at 30 or 300 mg/kg/day, failed to show any teratologic affect. These studies suggest that high doses of ferbam caused mild teratologic effects in rats. (Supported by the National Institute of Environmental Health Sciences, Contract No. NIH-NIEHS-72-2084.) |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Washington, D.C. |
| Conference Name | Thirteenth Annual Meeting of the Society of Toxicology |
| Conference Date | March 10–14, 1974 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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