The oral toxicology of dichlorodifluoromethane
Sherman, H; Barnes, JR; Stula, EF
HERO ID
2728459
Reference Type
Journal Article
Subtype
Abstract
Year
1974
Language
English
| HERO ID | 2728459 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 1974 |
| Title | The oral toxicology of dichlorodifluoromethane |
| Authors | Sherman, H; Barnes, JR; Stula, EF |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 29 |
| Issue | 1 |
| Page Numbers | 152 |
| Abstract | Dichlorodifluoromethane has been in use since 1967 as an immersion freezing agent for food. Male and female rats have been administered dichlorodifluoromethane for 2 years by intra-gastric intubation at dose levels of 25-11 and 250-130 mg/kg, starting with offspring that had been exposed to the compound in utero. Except for a very slight decrease in the rate of body weight gain by animals that received the higher dose level, no clinical signs of toxicity were observed. The oral administration of the test compound did not affect mortality, nor did it alter any of the clinical laboratory measurements (hematology, urine analysis, liver function test). After 16 months, there was no histologic evidence of toxicity attributable to the administration of the dichlorodifluoromethane. The compound was not teratogenic to rats; it did not interfere with reproduction and lactation, and it did not alter the dominant lethal mutation index in rats. Dichlorodifluoromethane has also been administered in the diet to dogs for 2 years at levels of 300 ppm (ca. 10 mg/kg) and 3000 ppm (ca. 100 mg/kg) without any evidence of toxicity. |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Washington, D.C. |
| Conference Name | Thirteenth Annual Meeting of the Society of Toxicology |
| Conference Date | March 10–14, 1974 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
|