Red cell 2,3-diphosphoglycerate and oxygen toxicity in rats
Weissberg, JB; Crapo, JD
HERO ID
2735234
Reference Type
Journal Article
Subtype
Abstract
Year
1974
Language
English
| HERO ID | 2735234 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 1974 |
| Title | Red cell 2,3-diphosphoglycerate and oxygen toxicity in rats |
| Authors | Weissberg, JB; Crapo, JD |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 29 |
| Issue | 1 |
| Page Numbers | 131-132 |
| Abstract | Studies were undertaken to investigate red cell 2,3-diphosphoglycerate (2,3-DPG) metabolism in rats exposed to high oxygen tensions. Previous investigators have shown that 2,3-DPG decreases the affinity of hemoglobin for oxygen by specifically binding to deoxyhemoglobin. Elevations in red cell 2,3-DPG with resultant enhanced availability of oxygen to tissues have been reported in instances of lowered arterial oxygen tension. If under high oxygen tensions 2,3-DPG concentrations decline, less oxygen would be available to tissues, and the toxic effects of oxygen may be reduced. Large male rats (greater than 9 weeks of age) were exposed to 100% O2. No change in red cell 2,3-DPG concentrations occurred after 24, 48 and 60 hr of exposure. A 31% increase in 2,3-DPG was observed after 24 hr of exposure to 10% O2. However, younger (3- to 4-week-old) male rats showed a 22% decline in red cell 2,3-DPG after 24 hr in 100% O2. This effect persisted throughout a 7-day exposure period. The younger animals were also shown to be less responsive to the toxic effects of oxygen. While older rats died after 60-72 hr of exposure to 100% O2, the young rats survived for prolonged periods. A differential response between young and older rats exposed to toxic levels of oxygen has been observed, and it is postulated that 2,3-DPG may have a role in protection against the toxic effects of oxygen. |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Washington, D.C. |
| Conference Name | Thirteenth Annual Meeting of the Society of Toxicology |
| Conference Date | March 10–14, 1974 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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