Redirected to reference 664363
Identification of Rodent Carcinogens by an Expert System
Rosenkranz, HS; Klopman, G
HERO ID
664363
Reference Type
Book/Book Chapter
Year
1990
Language
English
PMID
| HERO ID | 664363 |
|---|---|
| Year | 1990 |
| Title | Identification of Rodent Carcinogens by an Expert System |
| Book Title | Mutation and the Environment, Part B: Metabolism, Testing Methods, and Chromosomes |
| Authors | Rosenkranz, HS; Klopman, G |
| Editor | M.L. Mendelsohn; R.J. Albertini |
| Publisher Text | Wiley |
| City | New York |
| Volume | 340 |
| Page Numbers | 23-48 |
| Abstract | CASE, an artificial intelligence method for identifying structural determinants responsible for biological activity was applied to the U.S. National Toxicology Program (NTP) cancer bioassay results. CASE identified structures which were significantly associated with rodent carcinogenicity. On the basis of these structural determinants CASE exhibited a sensitivity of 0.98 and a specificity of 1.00. CASE showed a similarly remarkable performance in predicting the carcinogenicity, or lack thereof, of chemicals not in the NTP data base. A comparison between the activating structures (biophores) responsible for mutagenicity in Salmonella and rodent carcinogenicity showed a significant overlap, verifying that there are structural commonalities between the two phenomena. CASE also identified biophores significantly associated with the activity of non-genotoxic carcinogens, thereby suggesting the unexpected possibility that there is a structural commonality among the chemicals included in this group. A comparison between the biophores responsible for carcinogenicity in mice and rats resulted in the identification of common ("universal") biophores. It is suggested that agents which contain "universal" biophores are more likely to present a risk to human than carcinogens that do not possess such biophores. CASE also permitted the recognition of species-specific carcinogenic biophores. While the former are primarily electrophiles or potential electrophiles, the latter represent non-electrophilic structures. |
| Pmid | 2203007 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Cleveland, OH |
| Series | Progress in Clinical and Biological Research |
| Isbn | 9780471567929 |
| Conference Name | Fifth International Conference on Environmental Mutagens |
| Conference Date | July 10-15, 1989 |
| Comments | Journal: MENDELSOHN ISSN: |
| Is Public | Yes |
| Language Text | English |
| Keyword | <?xml version="1.0" encoding="UTF-8"?><kw>General Biology-Symposia</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Cytology and Cytochemistry-Animal</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Genetics and Cytogenetics-Animal</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Toxicology-General</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Neoplasms and Neoplastic Agents-Carcinogens and Carcinogenesis</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Physiology and Biochemistry of Bacteria</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Genetics of Bacteria and Viruses</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Enterobacteriaceae (1979- )</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Rodentia-Unspecified</kw> |
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