Distributions of heavy metals in maternal and cord blood and the association with infant birth weight in China
Hu, X; Zheng, T; Cheng, Y; Holford, T; Lin, S; Leaderer, B; Qiu, J; Bassig, BA; Shi, K; Zhang, Y; Niu, J; Zhu, Y; Li, Y; Guo, H; Chen, Q; Zhang, J; Xu, S; Jin, Y
HERO ID
2822165
Reference Type
Journal Article
Year
2015
Language
English
PMID
| HERO ID | 2822165 |
|---|---|
| In Press | No |
| Year | 2015 |
| Title | Distributions of heavy metals in maternal and cord blood and the association with infant birth weight in China |
| Authors | Hu, X; Zheng, T; Cheng, Y; Holford, T; Lin, S; Leaderer, B; Qiu, J; Bassig, BA; Shi, K; Zhang, Y; Niu, J; Zhu, Y; Li, Y; Guo, H; Chen, Q; Zhang, J; Xu, S; Jin, Y |
| Journal | Journal of Reproductive Medicine |
| Volume | 60 |
| Issue | 1-2 |
| Page Numbers | 21-29 |
| Abstract | OBJECTIVE To measure serum levels of heavy metals in Chinese pregnant women and their newborns, and to evaluate the association of these metals with infant birth weight STUDY DESIGN We measured serum concentrations of lead (Pb), thallium (Tl), cadmium (Cd), selenium (Se), arsenic (As), nickle (Ni), vanadium (V), cobalt (Co), and mercury (Hg) in 81 mother-infant pairs using an inductively coupled plasma mass spectrometry method. Multiple linear regression analyses were used to evaluate the associations of these heavy metals with infant birth weight. RESULTS Se, Pb, As, and Cd showed the highest detection rates (98.8%) in both the maternal and cord blood, followed by Tl, which was detected in 79.0% and 71.6% of the maternal and cord blood samples, respectively. Pb had the highest concentrations in both the maternal and cord blood samples of all toxic metals detected, with concentrations of 23.1 ng/g and 22.0 ng/g, respectively. No significant associations were observed between any heavy metals and birth weight. However, Tl in the maternal and cord blood was most notably inversely associated with birth weight. CONCLUSION Se intake was low in Chinese women and their newborns, whereas Pb had the highest concentrations in both the maternal and cord blood samples of all toxic metals detected. Tl was a unique pollution source in this population, and Tl levels were shown to have the largest effect on decreasing infant birth weight in this pilot study. Further research incorporating larger sample sizes is needed to investigate the effects of prenatal exposure to heavy metals—especially Tl and Pb—on birth outcomes in Chinese infants. |
| Pmid | 25745747 |
| Wosid | WOS:000348491600005 |
| Url | https://www.reproductivemedicine.com/toc/auto_abstract.php?id=24261 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | birth weight, heavy metals; environmental pollution; heavy metal poisoning; infant, newborn; intrauterine growth retardation; maternal exposure; maternal-fetal exchange; neonate; newborn; prenatal exposure delayed effects; selenium |