Significance of metallothionein expression in liver disease
Nagamine, T; Nakajima, K
HERO ID
2969858
Reference Type
Journal Article
Subtype
Review
Year
2013
Language
English
PMID
| HERO ID | 2969858 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2013 |
| Title | Significance of metallothionein expression in liver disease |
| Authors | Nagamine, T; Nakajima, K |
| Journal | Current Pharmaceutical Biotechnology |
| Volume | 14 |
| Issue | 4 |
| Page Numbers | 420-426 |
| Abstract | Hepatic metallothionein (MT) expression, with various isoforms, and varying cellular localizations is a useful marker for clinico-pathogenesis of liver diseases. In acute liver toxicity caused by cadmium, carbon tetrachloride, or acetaminophen, MT plays a protective role, via the scavenging of radical species. In chronic hepatitis C patients, hepatic MT levels appear to be a biological factor associated with the severity of HCV infection, and are associated with a better response to IFN therapy. Transgenic mice that express HBsAg in the liver show hepatocellular damage, inflammation, regeneration, hyperplasia, and, eventually, neoplasia. The MT isoform, MT-1 help mitigate HBV-induced hepatitis. Analysis of MT gene expression in the livers of chronic hepatitis B patients is useful for understanding the features of distinct liver diseases and for judging disease progression. A profound down-regulation of isoform MT-1G in hepatocellular carcinoma was observed in 63% of tumors relative to the adjacent nonmalignant liver. MT has been implicated in the control of p53 folding with zinc exchange. Therefore, it appears MT may play a role in the pathogenesis of hepatocellular carcinoma. Overall MT is linked to a variety of liver diseases. |
| Doi | 10.2174/1389201011314040006 |
| Pmid | 23590140 |
| Wosid | WOS:000326986000006 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Metallothionein; liver toxicity; hepatitis B; hepatitis C; hepatocellular carcinoma; liver fibrosis |