Effects of alcohols and diols on the phase behaviour of quaternary systems
Alany, RG; Rades, T; Agatonovic-Kustrin, S; Davies, NM; Tucker, IG
| HERO ID | 3037506 |
|---|---|
| In Press | No |
| Year | 2000 |
| Title | Effects of alcohols and diols on the phase behaviour of quaternary systems |
| Authors | Alany, RG; Rades, T; Agatonovic-Kustrin, S; Davies, NM; Tucker, IG |
| Journal | International Journal of Pharmaceutics |
| Volume | 196 |
| Issue | 2 |
| Page Numbers | 141-145 |
| Abstract | The aim of the current study was to investigate the effect of different co-surfactants on the phase behaviour of the pseudoternary system water:ethyl oleate:nonionic surfactant blend (sorbitan monolaurate/polyoxyethylene 20 sorbitan mono-oleate). Four aliphatic alcohols (1-propanol, 1-butanol, 1-hexanol and 1-octanol) and four 1,2-alkanediols (1,2-propanediol. 1,2-pentanediol, 1,2-hexanediol and 1,2-octanediol) were used. The co-surfactant-free system forms two different colloidal structures, a water-in-oil microemulsion (w/o ME) and lamellar liquid crystals (LC) and two coarse dispersions, water-in-oil (w/o EM) and oil-in-water (o/w EM) emulsions. Microemulsion region area (%ME), liquid crystalline region area (%LC), amount of amphiphile blend required to produce a balanced microemulsion (%AMPH) and amount of water solubilised (%W)were used as assessment criteria to evaluate the co-surfactants. Seven calculated physico-chemical descriptors were used to represent the different co-surfactants. 1-butanol, 1,2-hexanediol and 1,2-octanediol produced balanced MEs capable of solubilising a high percentage of both oil and water. A similarity was observed between the descriptors attributed to I-butanol and 1,2-hexanediol. The requirements of a co-surfactant molecule to produce a balanced microemulsion were: HLB Value 7.0-8.0, a carbon backbone of 4-6 atoms, percentage carbon of 60-65%, percentage oxygen of 20-30%, log P value 0.2-0.9 and log 1/S (S: aqueous solubility) close to zero. (C) 2000 Elsevier Science B.V. All rights reserved. |
| Doi | 10.1016/S0378-5173(99)00408-1 |
| Pmid | 10699705 |
| Wosid | WOS:000085847200004 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | microemulsions; cosurfactants; alcohols; diols; phase diagrams |