Safety Assessment of 1,2-Glycols as Used in Cosmetics
Johnson, W, Jr; Bergfeld, WF; Belsito, DV; Hill, RA; Klaassen, CD; Liebler, D; Marks, JG, Jr; Shank, RC; Slaga, TJ; Snyder, PW; Andersen, FA
HERO ID
3038919
Reference Type
Journal Article
Subtype
Review
Year
2012
Language
English
PMID
| HERO ID | 3038919 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2012 |
| Title | Safety Assessment of 1,2-Glycols as Used in Cosmetics |
| Authors | Johnson, W, Jr; Bergfeld, WF; Belsito, DV; Hill, RA; Klaassen, CD; Liebler, D; Marks, JG, Jr; Shank, RC; Slaga, TJ; Snyder, PW; Andersen, FA |
| Journal | International Journal of Toxicology |
| Volume | 31 |
| Issue | 5 Suppl |
| Page Numbers | 147S-168S |
| Abstract | Caprylyl glycol and related 1,2-glycols are used mostly as skin and hair conditioning agents and viscosity agents in cosmetic products, and caprylyl glycol and pentylene glycol also function as cosmetic preservatives. The Cosmetic Ingredient Review (CIR) Expert Panel noted that, while these ingredients are dermally absorbed, modeling data predicted decreased skin penetration of longer chain 1,2-glycols. Because the negative oral toxicity data on shorter chain 1,2-glycols and genotoxicity data support the safety of the 1,2-glycols reviewed in this safety assessment, the Panel concluded that these ingredients are safe in the present practices of use and concentration described in this safety assessment. |
| Doi | 10.1177/1091581812460409 |
| Pmid | 23064773 |
| Wosid | WOS:000328732500002 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | 1,2-glycols |