Histopathologic effects of nitrogen dioxide exposure and heat stress in cynomolgus monkeys
Busey, WM; Coate, WB; Badger, DW
HERO ID
34054
Reference Type
Journal Article
Subtype
Abstract
Year
1974
Language
English
| HERO ID | 34054 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 1974 |
| Title | Histopathologic effects of nitrogen dioxide exposure and heat stress in cynomolgus monkeys |
| Authors | Busey, WM; Coate, WB; Badger, DW |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 29 |
| Issue | 1 |
| Page Numbers | 130 |
| Abstract | Histopathologic studies were conducted on the lungs from male cynomolgus monkeys exposed continuously for 90 days, with and without heat stress, to 5 and 10 ppm of nitrogen dioxide. Similar studies were conducted on the lungs from air exposed monkeys with and without heat stress. Nitrogen dioxide-related microscopic alterations were seen in the respiratory bronchioles, alveolar ducts and adjacent interalveolar septa. These alterations were characterized by an interstitial infiltration of mononuclear macrophages, lymphocytes and occasionally polymorphonuclear leucocytes. Bronchiolar epithelial hyperplasia was also frequently seen in the monkeys exposed to both 5 and 10 ppm of nitrogen dioxide. Granular pneumonocyte hyperplasia was occasionally seen in alveoli adjacent to affected bronchioles. Focal pulmonary edema was present in the lungs from some monkeys exposed to 10 ppm of nitrogen dioxide. No microscopic morphological effect of heat stress was seen in the lungs from either the nitrogen dioxide-exposed or control monkeys. |
| Wosid | WOS:A1974T653800146 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Washington, DC |
| Conference Name | Thirteenth Annual Meeting of the Society of Toxicology |
| Conference Date | March 10–14, 1974 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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