[RETRACTED] Effects of di-isononyl phthalate on neuropeptide Y expression in differentiating human neuronal cells
Rendel, F; Alfredsson, CF; Bornehag, CG; Sundström, BE; Nånberg, E
HERO ID
3469427
Reference Type
Journal Article
Year
2016
Language
English
PMID
| HERO ID | 3469427 |
|---|---|
| In Press | No |
| Year | 2016 |
| Title | [RETRACTED] Effects of di-isononyl phthalate on neuropeptide Y expression in differentiating human neuronal cells |
| Authors | Rendel, F; Alfredsson, CF; Bornehag, CG; Sundström, BE; Nånberg, E |
| Journal | Basic & Clinical Pharmacology & Toxicology Online Pharmacology Online |
| Volume | 120 |
| Issue | 3 |
| Page Numbers | 318-323 |
| Abstract | Neuropeptide Y (NPY) is an abundant neuropeptide in the mammalian brain important for behavioural consequences of stress and energy metabolism. We have addressed possible effects of the phthalate DiNP on NPY expression in human SH-SY5Y cells, a neuronal in vitro differentiation model. Pico- to nanomolar doses of DiNP and its metabolite MiNP resulted in decreased NPY mRNA and peptide expression in retinoid-differentiated cells. Thus, dys-regulated NPY may be an adverse outcome for exposure to low doses of DiNP in human beings. This article is protected by copyright. |
| Doi | 10.1111/bcpt.12670 |
| Pmid | 27625336 |
| Wosid | WOS:000394538600016 |
| Url | https://search.proquest.com/docview/1859717229?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Neuropeptide Y; Phthalic Acids; RNA, Messenger; diisononyl phthalate; 4010KIX4CK; Tretinoin; 5688UTC01R; Index Medicus; RNA, Messenger -- metabolism; Tretinoin -- pharmacology; Cell Line, Tumor; Cell Differentiation; Phthalic Acids -- pharmacology; Neurons -- cytology; Neuropeptide Y -- metabolism; Neurons -- metabolism; Neurons -- drug effects |
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