[Protection and bidirectional effect of rhubarb anthraquinone and tannins for rats' liver]
Qin, LS; Zhao, HP; Zhao, YL; Ma, ZJ; Zeng, LN; Zhang, YM; Zhang, P; Yan, D; Bai, ZF; Li, Y; Hao, QX; Zhao, KJ; Wang, JB; Xiao, XH
| HERO ID | 3482070 |
|---|---|
| In Press | No |
| Year | 2014 |
| Title | [Protection and bidirectional effect of rhubarb anthraquinone and tannins for rats' liver] |
| Authors | Qin, LS; Zhao, HP; Zhao, YL; Ma, ZJ; Zeng, LN; Zhang, YM; Zhang, P; Yan, D; Bai, ZF; Li, Y; Hao, QX; Zhao, KJ; Wang, JB; Xiao, XH |
| Journal | Zhongguo Zhong-Xiyi Jiehe Zazhi |
| Volume | 34 |
| Issue | 6 |
| Page Numbers | 698-703 |
| Abstract | <strong>OBJECTIVE: </strong>To compare the bidirectional effect of rhubarb total anthraquinone (TA) and total tannins (TT) on rats' liver.<br /><br /><strong>METHODS: </strong>One hundred rats were randomly divided into 10 groups, i.e., the blank group, the model group, the blank + high dose TA group, the blank +low dose TA group, the blank + high dose TT group, the blank + low dose TT group, the model + high dose TA group, the model + low dose TA group, the model +high dose TT group, and the model + low dose TT group, 10 in each group. The carbon tetrachloride (CCI4) was used to prepare the acute liver injury rat model. TA and TT of rhubarb (at 5.40 g crude drugs/kg and 14.69 g crude drugs/kg) were intragastrically administrated to rats in all groups except the blank group and the model group, once daily for 6 successive days.The general state of rats, biochemical indices such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), laminin (LN), hyaluronic acid (HA), transforming growth factor beta1 (TGF-beta1), as well pathological results of rat liver tissues. Finally the protection laws of TA and TT for rats' liver were analyzed using factor analysis.<br /><br /><strong>RESULTS: </strong>Compared with the blank control group, all biochemical indices increased in the blank group (P < 0.05, P < 0.01). HA also increased in the blank + high dose TA group; AST, ALT, and HA also increased in the blank +high dose TT group (P < 0.05). Compared with the model group, AST, ALT, ALP, HA, and TGF-beta1 significantly decreased in the model + low dose TA group, the model + high dose TA group, the model + low dose TT group (P < 0.05, P < 0.01). Serum AST, ALT, and ALP also decreased in the model + high dose TT group (P < 0.05, P < 0.01). Pathological results showed that mild swollen liver cells in the model + high dose TA group. Fatty degeneration and fragmental necrosis around the central veins occurred in the blank + high dose TA group. The pathological injury was inproved in the model +low dose TA group. Two common factors, liver fibrosis and liver cell injury, were extracted by using factor analysis. TA showed stronger improvement of the two common factors than TT.<br /><br /><strong>CONCLUSIONS: </strong>Rhubarb TA and TT showed protective and harmful effects on rats' liver. At an equivalent dosage, TA had better liver protection than TT. High dose TT played a role in liver injury to some extent. |
| Pmid | 25046953 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | Chinese |