Dermal absorption and urinary elimination of N-methyl-2-pyrrolidone
Bader, M; Keener, SA; Wrbitzky, R
HERO ID
3539719
Reference Type
Journal Article
Year
2005
Language
English
PMID
| HERO ID | 3539719 |
|---|---|
| In Press | No |
| Year | 2005 |
| Title | Dermal absorption and urinary elimination of N-methyl-2-pyrrolidone |
| Authors | Bader, M; Keener, SA; Wrbitzky, R |
| Journal | International Archives of Occupational and Environmental Health |
| Volume | 78 |
| Issue | 8 |
| Page Numbers | 673-676 |
| Abstract | <strong>OBJECTIVES: </strong>The dermal absorption of the solvent N-methyl-2-pyrrolidone (NMP) and its elimination in urine was investigated in an experimental study.<br /><br /><strong>METHODS: </strong>Seven volunteers were exposed to 1045 mg of liquid NMP under occlusive conditions for 2 h. Urine was collected before, during and up to 72 h after the exposure and analysed for NMP by GC/MS after liquid-liquid extraction. Additionally, the remaining NMP in the pads was determined to estimate the total dermal uptake.<br /><br /><strong>RESULTS: </strong>The concentration of NMP in urine increased rapidly after beginning of the exposure up to 1 h after the exposure was completed. A peak concentration of 1,836+/-863 microg/l was observed, the half-life in urine was 3.2 h. About 0.5% of the absorbed dose was excreted metabolically unchanged. An average dermal absorption of 5.5 mg cm(-2) h(-1) was calculated.<br /><br /><strong>CONCLUSIONS: </strong>The results of this study show that the percutaneous absorption of NMP may contribute significantly to the overall uptake of the solvent, e.g. in the workplace. Therefore, a biological monitoring of NMP exposed workers is essential for occupational-medical surveillance. |
| Doi | 10.1007/s00420-005-0008-0 |
| Pmid | 16001206 |
| Wosid | WOS:000232779200010 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |