Percutaneous delivery of α-melanocyte-stimulating hormone for the treatment of imiquimod-induced psoriasis
Shah, PP; Desai, PR; Boakye, CH; Patlolla, R; Kikwai, LC; Babu, RJ; Singh, M
HERO ID
3540726
Reference Type
Journal Article
Year
2016
Language
English
PMID
| HERO ID | 3540726 |
|---|---|
| In Press | No |
| Year | 2016 |
| Title | Percutaneous delivery of α-melanocyte-stimulating hormone for the treatment of imiquimod-induced psoriasis |
| Authors | Shah, PP; Desai, PR; Boakye, CH; Patlolla, R; Kikwai, LC; Babu, RJ; Singh, M |
| Journal | Journal of Drug Targeting |
| Volume | 24 |
| Issue | 6 |
| Page Numbers | 537-547 |
| Abstract | <strong>PURPOSE: </strong>α-Melanocyte-stimulating hormone (α-MSH) is an endogenous peptide hormone with anti-inflammatory responses. We developed topical formulation(s) of α-MSH to reduce psoriasis-related inflammation.<br /><br /><strong>METHODS: </strong>Transcutol (TC) and n-methyl 2-pyrrolidone (NMP) were used to formulate a gel for α-MSH. Skin permeation and dermal microdialysis of the solution and optimized gel were performed. The inflammatory response of α-MSH gel was investigated in imiquimod-induced psoriasis mouse model. Histology and immunohistochemistry were then performed on treated skin.<br /><br /><strong>RESULTS: </strong>Solution comprising 50%w/w TC and 10%w/w NMP showed higher (p < 0.05) skin retention (0.27 ± 0.024 µg of α-MSH/mg of skin) than solutions containing either 50% w/w TC or 10% w/w NMP at 24 h. Dispersion of α-MSH in Carbopol Ultrez 10 produced a uniform dispersion. α-MSH gel showed pseudoplastic flow with thixotropic behavior. Dermal microdialysis results suggested that skin permeation of gel after 5 h was 1.9-folds higher than the solution. Further, gel-treated psoriatic-like plaque skin sections showed significant (p < 0.05) decrease in the expression of a melanocortin receptor, in the psoriasis area and severity index score and transepidermal water loss compared to the solution.<br /><br /><strong>CONCLUSION: </strong>TC, NMP and Carbopol Ultrez 10 form a stable gel with improved skin permeation of α-MSH for a reduction in psoriasis-associated inflammation. |
| Doi | 10.3109/1061186X.2015.1103743 |
| Pmid | 26582563 |
| Wosid | WOS:000373285100007 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: ISSN: |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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