TANDEM MASS SPECTROMETRY CHARACTERIZATION OF ESTERIFIED CYCLODEXTRINS
Peptu, C; Harabagiu, V
| HERO ID | 3575130 |
|---|---|
| In Press | No |
| Year | 2013 |
| Title | TANDEM MASS SPECTROMETRY CHARACTERIZATION OF ESTERIFIED CYCLODEXTRINS |
| Authors | Peptu, C; Harabagiu, V |
| Journal | Digest Journal of Nanomaterials and Biostructures |
| Volume | 8 |
| Issue | 4 |
| Page Numbers | 1551-1561 |
| Abstract | The tandem mass spectrometry (MS/MS) characterization of cyclodextrin derivatives, namely randomly esterified 6-O-(3-hydroxybutyril)-beta-cyclodextrin (HBCD) and triacetyl-beta-cyclodextrin (TABCD) is described. The chosen compounds share certain structural similarities which are exploited in order to establish a general approach in their tandem MS characterization. The TABCD commercial product is fully esterified and presents in single stage MS a single peak while HBCD presents a molecular weight distribution due to the variation of the substitution degree. HBCD product was obtained via ring opening of beta-butyrolactone in the presence of beta-cyclodextrin (CD). First, the specific fragmentation pathways are established for protonated and sodiated TABCD parent ions and, based on the established fragmentation behaviour, HBCD compounds are analyzed. Our findings indicate that in MS/MS analysis of esterified cyclodextrins the cleavage of the substituents can be selectively induced thus offering information on the substitution patterns. Moreover, we demonstrate, using tandem MS technique, that beta-butyrolactone monomer units are attached to the CD molecule not as oligomer chains but as singly esterified molecules. |
| Wosid | WOS:000327818000020 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | beta-cyclodextrin; beta-butyrolactone; tryacetil-beta-cyclodextrin; ESI MS; Tandem MS; Collision induced dissociations |