Aggregation induced emission enhancement and growth of naphthalimide nanoribbons via J-aggregation: insight into disaggregation induced unfolding and detection of ferritin at the nanomolar level
Meher, N; Chowdhurya, SRoy; Iyer, PK
| HERO ID | 3575714 |
|---|---|
| In Press | No |
| Year | 2016 |
| Title | Aggregation induced emission enhancement and growth of naphthalimide nanoribbons via J-aggregation: insight into disaggregation induced unfolding and detection of ferritin at the nanomolar level |
| Authors | Meher, N; Chowdhurya, SRoy; Iyer, PK |
| Volume | 4 |
| Issue | 36 |
| Page Numbers | 6023-6031 |
| Abstract | A series of novel V-shaped naphthalimide derivatives are reported herein, designed through a strategy to achieve aggregation induced emission (AIE), giving rise to unexpected self-assembly properties. This includes an aggregation induced emission enhancement (AIEE) active small organic molecule viz. naphthalimide derivative functionalized with 8-hydroxyquinoline (alpha-NQ), that spontaneously forms highly fluorescent "nanoribbon'' like structures with < 100 nm diameter and hundreds of micron length in aqueous media irrespective of concentration and surface at room temperature. The classical head-to-tail p-p stacking, as revealed by the single crystal X-ray study, was found to be the main driving force for the J-type aggregation with unique self-aggregating behavior. A comparative mechanistic study confirms that the N-atom in the hydroxyquinoline moiety is responsible for directing the entire molecular behavior in solution as well as in its aggregated state. These alpha-NQ nanoribbons formed in aqueous media were found to be highly sensitive and selective towards the multi-functional nonheme protein ferritin (K-sv = 0.83 x 107 M-1) with a limit of detection 67.25 x 10(-11) M (0.33 ng mu L-1) under physiological conditions, which serves as a well-known inflammatory marker for various diseases. The fluorescent nanoribbons were also found to modify the a-helix content of ferritin, thereby inducing conformational changes in their secondary structure as confirmed through circular dichroism (CD) spectroscopy techniques. Collectively, these findings improve the fundamental understanding of the self-assembly of AIEE active molecules along with the photophysical properties of core substituted naphthalimide derivatives that report the highest sensitivity towards ferritin in the presence of a bright AIEEgen under physiological conditions. |
| Doi | 10.1039/c6tb01746k |
| Wosid | WOS:000384233900007 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal:JOURNAL OF MATERIALS CHEMISTRY B 2050-750X |
| Is Public | Yes |