Multifunctional Mesoporous Silica Material Used for Detection and Adsorption of Cu2+ in Aqueous Solution and Biological Applications in vitro and in vivo
Meng, Q; Zhang, X; He, C; He, G; Zhou, P; Duan, C
| HERO ID | 3575811 |
|---|---|
| In Press | No |
| Year | 2010 |
| Title | Multifunctional Mesoporous Silica Material Used for Detection and Adsorption of Cu2+ in Aqueous Solution and Biological Applications in vitro and in vivo |
| Authors | Meng, Q; Zhang, X; He, C; He, G; Zhou, P; Duan, C |
| Journal | Advanced Functional Materials |
| Volume | 20 |
| Issue | 12 |
| Page Numbers | 1903-1909 |
| Abstract | An inorganic-organic silica material (SBA-P2), prepared by immobilization of the 1,8-naphthalimide-based receptor P2 within the channels of the mesoporous silica material SBA-15, is characterized by transmission electron microscopy and several spectroscopic methods. SBA-P2 features a high affinity Cu2+-specific fluorescence response in aqueous solution with a detection limit for Cu2+ of ca. 0.65 ppb (10 x 10(M)(-9)) under optimized conditions. It can extract Cu2+ from the solution with only trace amounts remaining. Through isolating of the toxic ions within the mesopores of the silica, SBA-P2 has the potential to work as a toxicide for Cu2+ in living systems. The fluorogenical responses are reversible and do not vary over a broad (4.0 to 9.0) pH range suitable for application under physiological conditions. The fluorescence responses of Cu2+ in vitro (human breast cancer cells) and in vivo (five-day-old zebrafish) demonstrate the possibility of further application in biology. |
| Doi | 10.1002/adfm.201000080 |
| Wosid | WOS:000279707200004 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |