Naphthalimide hydroperoxides as photonucleases: substituent effects and structural basis
Tao, ZF; Qian, XH
| HERO ID | 3575857 |
|---|---|
| In Press | No |
| Year | 1999 |
| Title | Naphthalimide hydroperoxides as photonucleases: substituent effects and structural basis |
| Authors | Tao, ZF; Qian, XH |
| Journal | Dyes and Pigments |
| Volume | 43 |
| Issue | 2 |
| Page Numbers | 139-145 |
| Abstract | A variety of naphthalimide hydroperoxides as novel photochemical DNA cleavers were synthesized and evaluated. Their photochemical DNA-cleaving abilities depend on the substituents on the aromatic moiety. The DNA-cleaving differences of these hydroperoxides may result from the differences of the intercalating ability of the naphthalene moiety. X-ray single crystal structure of a representative compound 1 was determined, and showed that all endocyclic atoms were coplanar, indicating a structural basis for potential and efficient DNA intercalation by 1. (C) 1999 Elsevier Science Ltd. All rights reserved. |
| Doi | 10.1016/s0143-7208(99)00037-6 |
| Wosid | WOS:000081949500009 |
| Url | <Go to ISI>://WOS:000081949500009 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | DNA cleaver; DNA intercalator; naphthalimide; peroxides; X-ray single crystal structure; hydroxyl radicals |