Flurothyl seizure susceptibility in rats following prenatal methylazoxymethanol treatment
Baraban, SC; Schwartzkroin, PA
| HERO ID | 3828377 |
|---|---|
| In Press | No |
| Year | 1996 |
| Title | Flurothyl seizure susceptibility in rats following prenatal methylazoxymethanol treatment |
| Authors | Baraban, SC; Schwartzkroin, PA |
| Journal | Epilepsy Research |
| Volume | 23 |
| Issue | 3 |
| Page Numbers | 189-194 |
| Abstract | Methylazoxymethanol acetate (MAMac) is a potent teratogenic agent which can produce ectopic cell placement in developing rat brains. In the present study, we evaluated (i) whether prenatal exposure to MAMac results in a lowered seizure threshold to flurothyl and (ii) if there is a correlation between the number of ectopic cells in MAMac-exposed hippocampus and flurothyl-induced seizure latency. In 60 day old (P60) rats exposed to MAMac in utero, the latencies to myoclonic jerk (173 +/- 2.3 s) and forelimb clonus (215 +/- 4.6 s) were significantly shorter than those of controls (200 +/- 6.9 s and 238 +/- 8.8 s, respectively). MAMac also increased the proportion of flurothyl-treated rats that progressed from bilateral forelimb clonus to generalized tonic-clonic seizures (control: 33%; MAMac: 91%). Shorter seizure latencies were associated with an increased number of ectopic pyramidal cells in region CA1/CA2. These results suggest seizure susceptibility is enhanced in an animal model (MAMac) characterized by abnormal neuronal migration. |
| Doi | 10.1016/0920-1211(95)00094-1 |
| Pmid | 8739122 |
| Wosid | WOS:A1996UL44900002 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | ectopic; flurothyl; hippocampus; rat; seizure |