Biotransformation pathways of fluorotelomer-based polyfluoroalkyl substances: a review
Butt, CM; Muir, DC; Mabury, SA
HERO ID
3859245
Reference Type
Journal Article
Subtype
Review
Year
2014
Language
English
PMID
| HERO ID | 3859245 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2014 |
| Title | Biotransformation pathways of fluorotelomer-based polyfluoroalkyl substances: a review |
| Authors | Butt, CM; Muir, DC; Mabury, SA |
| Journal | Environmental Toxicology and Chemistry |
| Volume | 33 |
| Issue | 2 |
| Page Numbers | 243-267 |
| Abstract | The study reviews the current state of knowledge regarding the biotransformation of fluorotelomer-based compounds, with a focus on compounds that ultimately degrade to form perfluoroalkyl carboxylates (PFCAs). Most metabolism studies have been performed with either microbial systems or rats and mice, and comparatively few studies have used fish models. Furthermore, biotransformation studies thus far have predominately used the 8:2 fluorotelomer alcohol (FTOH) as the substrate. However, there have been an increasing number of studies investigating 6:2 FTOH biotransformation as a result of industry's transition to shorter-chain fluorotelomer chemistry. Studies with the 8:2 FTOH metabolism universally show the formation of perfluorooctanoate (PFOA) and, to a smaller fraction, perfluorononanoate (PFNA) and lower-chain-length PFCAs. In general, the overall yield of PFOA is low, presumably because of the multiple branches in the biotransformation pathways, including conjugation reactions in animal systems. There have been a few studies of non-FTOH biotransformation, which include polyfluoroalkyl phosphates (PAPs), 8:2 fluorotelomer acrylate (8:2 FTAC), and fluorotelomer carboxylates (FTCAs, FTUCAs). The PAPs compounds and 8:2 FTAC were shown to be direct precursors to FTOHs and thus follow similar degradation pathways. |
| Doi | 10.1002/etc.2407 |
| Pmid | 24114778 |
| Wosid | WOS:000329556600001 |
| Url | https://search.proquest.com/docview/1762137227?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE); Precursors; Pathways; Degradation; Biotransformation; Microorganisms; Carboxylates; Metabolism |