Preparative-scale synthesis of amino coumarins through new sequential nitration and reduction protocol
Chaudhari, HK; Pahelkar, A; Takale, BS
| HERO ID | 4132342 |
|---|---|
| In Press | No |
| Year | 2017 |
| Title | Preparative-scale synthesis of amino coumarins through new sequential nitration and reduction protocol |
| Authors | Chaudhari, HK; Pahelkar, A; Takale, BS |
| Journal | Tetrahedron Letters |
| Volume | 58 |
| Issue | 43 |
| Page Numbers | 4107-4110 |
| Abstract | In contrast to the conventional deleterious approach for nitration (for example HNO3/H2SO4) and for reduction (for example Zn/HCl), we hypothesized that sensitive heterocycles such as coumarins could not withstand with those hard conditions. Hence, while studying this reaction sequence to prepare amino coumarins (which is our ongoing project to synthesize antitubercular coumarin agents), we came across mild and greener reagent for nitration using calcium nitrate (Ca(NO3)(2)center dot 4H(2)O; lime nitrate), and reduction using D-glucose. These two mild, chemoselective, high yielding methods are discussed herein. (C) 2017 Elsevier Ltd. All rights reserved. |
| Doi | 10.1016/j.tetlet.2017.09.040 |
| Wosid | WOS:000413386300019 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | Amines; Coumarins; Nitration; Pharmaceuticals; Reduction |