Iodine-loaded metal organic framework as growth-triggered antimicrobial agent
Au-Duong, AN; Lee, CK
| HERO ID | 4132479 |
|---|---|
| In Press | No |
| Year | 2017 |
| Title | Iodine-loaded metal organic framework as growth-triggered antimicrobial agent |
| Authors | Au-Duong, AN; Lee, CK |
| Journal | Materials Science and Engineering C: Materials for Biological Applications |
| Volume | 76 |
| Page Numbers | 477-482 |
| Abstract | Zeolitic imidazolate framework-8 (ZIF-8) is one of easily available metal organic frameworks because of its facile preparation via mixing aqueous solutions of zinc nitrate and 2-methylimidazole. It turned into a very effective pH-responsive bactericide after loading with iodine. Approximately, 0.9g of iodine could be readily loaded into one gram of ZIF-8 from iodine dissolved n-heptane solution. Both Gram-negative Escherichia coli and Gram-positive Staphylococcus epidermidis and Staphylococcus aureus could be very effectively killed by iodine loaded ZIF-8 (ZIF-8@I) at pH6.0 within 3min. In contrast, at pH above 7.0, no appreciable antimicrobial activity could be detected. The bacteria killing effect is resulted from the iodine released from ZIF-8@I disintegrated at acidic pH. ZIF-8@I coated surface also showed its acidic pH-triggered antimicrobial activity against deposited bacterial cells. The antimicrobial activity of ZIF-8@I against actively grown bacterial lawns on a pH neutral agar plate was also observed. The result demonstrates that iodine was released from the disintegrated ZIF-8@I to kill bacteria in response to the bacterial growth-induced pH lowering. |
| Doi | 10.1016/j.msec.2017.03.114 |
| Pmid | 28482553 |
| Wosid | WOS:000405541600057 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |