Synthesis and Cytotoxic Evaluation of Novel C-10 Nitrate Derivatives of Colchicine
Shen, LiH; Lu, XinQ; Wang, Bo; Wang, HaiX; Liu, ShuM
| HERO ID | 4132547 |
|---|---|
| In Press | No |
| Year | 2016 |
| Title | Synthesis and Cytotoxic Evaluation of Novel C-10 Nitrate Derivatives of Colchicine |
| Authors | Shen, LiH; Lu, XinQ; Wang, Bo; Wang, HaiX; Liu, ShuM |
| Journal | Journal of the Chemical Society of Pakistan |
| Volume | 38 |
| Issue | 4 |
| Page Numbers | 755-761 |
| Abstract | In our continuing search for more potent anticancer agent, eight novel nitrates couple with C-10 colchicine nitric oxide-releasing derivatives (5a-f and 7a-b) were prepared. These target compounds were assayed for their anti-tumor activity in vitro against four cancer cell lines, including human hepatocellular carcinoma cells (BEL7402), human ovary carcinoma cells (A2780), human lung adenocarcinoma cells (A549) and human breast carcinoma cells (MCF7). Preliminary results indicated that most of them exhibited significant cytotoxic effect toward cancer cells. Compound 7a was investigated further for its more potent cytotoxicity than colchicine. |
| Wosid | WOS:000390363100020 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | Nitrates; Colchicine C-10 derivatives; Anti-tumor activity |