Effects of treatment-induced mortality and tumor-induced mortality on tests for carcinogenicity in small samples
Bailer, AJ; Portier, CJ
| HERO ID | 41531 |
|---|---|
| In Press | No |
| Year | 1988 |
| Title | Effects of treatment-induced mortality and tumor-induced mortality on tests for carcinogenicity in small samples |
| Authors | Bailer, AJ; Portier, CJ |
| Journal | Biometrics |
| Volume | 44 |
| Issue | 2 |
| Page Numbers | 417-431 |
| Abstract | Statistical tests of carcinogenicity are shown to have varying degrees of robustness to the effects of mortality. Mortality induced by two different mechanisms is studied - mortality due to the tumor of interest, and mortality due to treatment independent of the tumor. The two most commonly used tests, the life-table test and the Cochran-Armitage linear trend test, are seen to be highly sensitive to increases in treatment lethality using small-sample simulations. Increases in tumor lethality are seen to affect the performance of commonly used prevalence tests such as logistic regression. A simple survival-adjusted quantal response test appears to be the most robust of all the procedures considered. |
| Doi | 10.2307/2531856 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ECRIB.Biometrics 44: 417-431. |
| Is Public | Yes |
| Language Text | English |