Effects of short- and long-term exposure to ozone on heart rate and blood pressure of emphysematous rats
Uchiyama, I; Yokoyama, E
HERO ID
42051
Reference Type
Journal Article
Year
1989
Language
English
PMID
| HERO ID | 42051 |
|---|---|
| In Press | No |
| Year | 1989 |
| Title | Effects of short- and long-term exposure to ozone on heart rate and blood pressure of emphysematous rats |
| Authors | Uchiyama, I; Yokoyama, E |
| Journal | Environmental Research |
| Volume | 48 |
| Issue | 1 |
| Page Numbers | 76-86 |
| Abstract | Electrocardiogram and arterial blood pressure of elastase-treated emphysematous rats (E rats) and saline-treated control rats (S rats) were recorded continuously during exposure to either 1 ppm ozone (O3) for 3 hr or 0.5 ppm O3 for 6 hr. The heart rates (HRs) of both groups decreased to about 50 and 65% of the initial levels at the end of 1 ppm and 0.5 ppm O3 exposure, respectively. Mean arterial blood pressures (MAPs) also decreased to about 76 and 82%, respectively. There was no significant difference in these responses between E and S rats, although the levels of HRs and MAPs of the E rats were always a little lower than those of the S rats. Another group of E and S rats was continuously exposed to 0.2 ppm O3 for 4 weeks. The HRs of both E and S groups decreased to about 81 and 88% of the initial levels on the first day, respectively, although they recovered completely by the third day. No significant difference in the variation of HRs during exposure was noted between E and S rats. However the HR responses of these rats to a challenge exposure of 0.8 ppm O3 for 1.5 hr appeared to be different. That is, S rats were more tolerant of the challenge exposure to O3 for 1.5 hr than the E rats. |
| Doi | 10.1016/S0013-9351(89)80087-8 |
| Pmid | 2914568 |
| Wosid | WOS:A1989T238400009 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Environ. Res. 48: 76-86. |
| Is Public | Yes |
| Language Text | English |
| Is Peer Review | Yes |
| Relationship(s) |
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