Heptoprotective Role of Artemisia scoparia Waldst. and Kit Against CCl4-induced Toxicity in Rats
Waris, TS; Khan, MR; Shah, NAli; Shuaib, M; Hussain, F; Ishaq, M; Kamal, Zul; Zeb, U; Ali, S; Ali, K; Ahmed, S; Hussain, F
| HERO ID | 4388162 |
|---|---|
| In Press | No |
| Year | 2018 |
| Title | Heptoprotective Role of Artemisia scoparia Waldst. and Kit Against CCl4-induced Toxicity in Rats |
| Authors | Waris, TS; Khan, MR; Shah, NAli; Shuaib, M; Hussain, F; Ishaq, M; Kamal, Zul; Zeb, U; Ali, S; Ali, K; Ahmed, S; Hussain, F |
| Journal | Polish Journal of Environmental Studies |
| Volume | 27 |
| Issue | 3 |
| Page Numbers | 1307-1314 |
| Abstract | In this study, the methanol extract of Artemisia scoparia was evaluated for its protective potential against carbon tetrachloride (CCl4)-induced hepatic toxicity. Seven groups of mature albino rats were used in the course of the experiment and each group was treated with specific doses of plant extract and CCl4. Silymarin was used as a standard protective drug. The results of the experiment revealed that Artemisia scoparia plant extract was successful in fighting CCl4 toxicity as it clearly reduced the elevated levels of liver serum markers (alkaline phosphatase and alkaline aminotransferase), lipid peroxidation, nitrite content, and H2O2 on one side while enhancing the levels of antioxidant enzymes (catalase, peroxidase, superoxide dismutase, glutathione-s-transferase, gamma-Glutamyltranspeptidase, and glutathione reductase) and protein content. It also protected DNA from the damaging effects of CCl4. The findings of this study demonstrate that Artemisia scoparia plant extract plays a significant role in preventing the hepatic damages instigated with CCl4 and can be used as a protective agent against oxidative stress-associated disorders. |
| Doi | 10.15244/pjoes/74018 |
| Wosid | WOS:000427520400036 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | Artemisia scoparia; hepatoprotective; rats; folk use |