Formulation studies of microemulsions for topical applications of acyclovir
Peira, E; Chirio, D; Carlotti, ME; Spagnolo, R; Trotta, M
| HERO ID | 4683785 |
|---|---|
| In Press | No |
| Year | 2009 |
| Title | Formulation studies of microemulsions for topical applications of acyclovir |
| Authors | Peira, E; Chirio, D; Carlotti, ME; Spagnolo, R; Trotta, M |
| Journal | Journal of Drug Delivery Science and Technology |
| Volume | 19 |
| Issue | 3 (Jun 2009) |
| Page Numbers | 191-196 |
| Abstract | Microemulsions prepared using 1-decanol, oleic acid or oleyl alcohol as oils, Transcutol and 1,2-hexanediol as surfactant mixture and phosphate buffer pH 6.0 as aqueous phase were studied to verify the effect of the oils on pig-skin permeation and accumulation of acyclovir (ACV). Pseudoternary phase diagrams were constructed in the absence and in the presence of ACV. ACV-containing microemulsions had a restricted area of existence compared to those without the drug. A cationic charge-inducing agent, L-alanine benzyl ester, was added to the formulations to prepare positively-charged microemulsions. Full-thickness pig ear skin was used for ACV permeation experiments using positively-andnegatively-charged microemulsions and a control suspension. The presence of oleyl alcohol or oleic acid increased the flux but not the drug skin accumulation compared to a control suspension, while the use of the cationic charge-inducing agent had no influence on the formulation performance. A two-fold increase in ACV accumulation was found using the microemulsions containing 1-decanol, maintaining intact the structure of the stratum corneum, as demonstrated by the DSC analysis. Microemulsions containing 1-decanol could significantly optimize drug targeting, maintaining the structure of the stratum corneum intact. |
| Doi | 10.1016/S1773-2247(09)50035-4 |
| Wosid | WOS:000266983900006 |
| Is Certified Translation | No |
| Dupe Override | 4683785 |
| Is Public | Yes |
| Keyword | Drug delivery; Skin; Stratum corneum; Oils; Ear; acyclovir; Esters; Topical application; Phosphate; L-Alanine; alcohols; Oleic acid; pH effects; Surfactants |