Development of ketoconazole nanovesicular system using 1,2-hexanediol and 1,4-cyclohexanediol for dermal targeting delivery: Physicochemical characterization and in vitro/in vivo evaluation
Wang, J; Guo, F; Ma, Man; Li, Nan; Tan, F
HERO ID
4683790
Reference Type
Journal Article
Year
2014
Language
English
| HERO ID | 4683790 |
|---|---|
| In Press | No |
| Year | 2014 |
| Title | Development of ketoconazole nanovesicular system using 1,2-hexanediol and 1,4-cyclohexanediol for dermal targeting delivery: Physicochemical characterization and in vitro/in vivo evaluation |
| Authors | Wang, J; Guo, F; Ma, Man; Li, Nan; Tan, F |
| Journal | Journal of Nanoparticle Research |
| Volume | 16 |
| Issue | 7 (Jul 2014) |
| Page Numbers | 2505 |
| Abstract | The present study was aimed at the encapsulation of ketoconazole (KCZ) in the novel modified nanovesicles for dermal targeting delivery. To this purpose, innovative modified vesicles were prepared with soy phospholipid and aqueous solutions containing different concentrations of two targeting modifiers, 1,2-hexanediol and 1,4-cyclohexanediol. Conventional liposomes, with soy phospholipid and cholesterol, were used as control. The prepared formulations were characterized in terms of entrapment efficiency, size distribution, morphology, and stability. Dermal KCZ targeting delivery from modified vesicles was investigated in vitro and in vivo through newborn pig and rat skin, respectively. All vesicles showed a mean size ranging from 58 to 147 nm with fairly narrow size distribution and drug entrapment efficiency between 20 and 75 %. Results of in vitro and in vivo studies indicated that modified vesicles provided an improved KCZ targeting delivery into skin layers. Images of the confocal laser scanning microscopy analyses supported the conclusion that modified vesicles could enhance the drug deposition into the skin strata and reduce the drug permeation into the blood, due to a synergic effect of phospholipid and modifiers. Finally, histological evaluation showed that KCZ-loaded modified vesicles caused no irritation to the skin. The results obtained encouraged the use of the KCZ-loaded modified vesicles as the formulation for the potential topical treatment of fungal infections. |
| Doi | 10.1007/s11051-014-2505-0 |
| Wosid | WOS:000338720600001 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Ketoconazole; 1,2-Hexanediol; 1,4-Cyclohexanediol; Modified nanovesicles; Dermal targeting delivery |