Safety of a new preservative system containing 1,2-hexanediol and caprylyl glycol for use in cosmetic products
Levy, S; Dulichan, A
HERO ID
4684031
Reference Type
Journal Article
Subtype
Abstract
Year
2008
Language
English
| HERO ID | 4684031 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 2008 |
| Title | Safety of a new preservative system containing 1,2-hexanediol and caprylyl glycol for use in cosmetic products |
| Authors | Levy, S; Dulichan, A |
| Journal | Journal of the American Academy of Dermatology |
| Volume | 58 |
| Issue | 2 |
| Page Numbers | AB55-AB55 |
| Abstract | Background: Traditional preservation systems currently used in cosmetic and skin care products are safe and effective. New ingredients with similar efficacy are continually being introduced to fulfill this function. Objective: To study the potential for delayed type IV allergic hypersensitivity and irritation of a new preservative system containing 1,2-hexanediol and caprylyl glycol. Methods: A 200-subject repeat insult patch test (RIPT) was performed. A 15% mixture of 1,2-hexanediol and caprylyl glycol (equal parts of the two ingredients) in carbomer gel was placed under a series of 9 continuous occlusive induction patches, each 48 hours in duration. Three induction patches were applied each week, for a total of 3 weeks. Following a 10-day rest period during which no patches were applied, a single challenge application using the same mixture was applied and left on for 48 hours and read at 48 and 72 hours postapplication. A cosmetic formulation containing this same preservation system at an actual use concentration was tested by the same RIPT protocol. Results: Two hundred and twelve subjects completed the study. One hundred and sixty-eight were female and 44 were male ranging in age from 18 to 70 years. No reactions were seen during the induction or challenge phases. An additional 212 subjects were enrolled in a separate RIPT that evaluated the cosmetic formulation containing the same preservation system. No delayed type IV allergic hypersensitivity or irritation reactions were observed. Conclusion: A new preservative system utilizing 1,2-hexanediol and caprylyl glycol did not induce delayed type IV allergic hypersensitivity or irritation in human subjects. |
| Wosid | WOS:000252700800220 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |