Synthesis of biotin-labelled core glycans of GPI anchors and their application in the study of GPI interaction with pore-forming bacterial toxins
Gao, J; Zhou, Z; Guo, J; Guo, Z
| HERO ID | 4739808 |
|---|---|
| In Press | No |
| Year | 2017 |
| Title | Synthesis of biotin-labelled core glycans of GPI anchors and their application in the study of GPI interaction with pore-forming bacterial toxins |
| Authors | Gao, J; Zhou, Z; Guo, J; Guo, Z |
| Journal | Chemical Communications |
| Volume | 53 |
| Issue | 46 |
| Page Numbers | 6227-6230 |
| Abstract | A convergent strategy was developed for the first-time synthesis of biotin-labeled GPI core glycans. These GPI conjugates are useful for various biological studies showcased by their application in the scrutiny of pore-forming bacterial toxin-GPI interaction, revealing that the phosphate group at the GPI inositol 1-O-position had a significant impact on GPI-toxin binding. |
| Doi | 10.1039/c7cc03056h |
| Pmid | 28537279 |
| Wosid | WOS:000402728600011 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |