Identification of fluorochemicals in human sera. I. American Red Cross adult blood donors
HERO ID
4745344
Reference Type
Technical Report
Year
2002
Language
English
| HERO ID | 4745344 |
|---|---|
| Year | 2002 |
| Title | Identification of fluorochemicals in human sera. I. American Red Cross adult blood donors |
| Authoring Organization | 3M Company |
| Publisher Text | U.S. Environmental Protection Agency |
| City | Washington, D.C. |
| Abstract | Through cooperation with six American Red Cross blood banks, 645 serum samples . from adult donors (ages 20-69, equally represented of both sexes) were obtained for fluorochemical analyses. Blood bank locations were Los Angeles (CA), Portland (OR), Minneapolis-St. Paul (MN), Charlotte (NC), Hagerstown (MD) and Boston (MA). Samples were void of personal identifiers. Age, gender and location were the only known demographic factors. Sera samples were extracted and quantitatively analyzed for seven fluorochemicals using high-pressure liquid chromatography/electrospray tandem mass spectrometry and evaluated versus an extracted curve from a human plasma matrix. The seven fluorochemicals were perfluorooctanesulfonate (PFOS, CsF11SO3); N-ethyl pertluorooctanesulfonamidoacetate (PFOSAA, C8F 17SO2N (CH2CH3)CH2COO-); Nmethyl perfluorooctanesulfonamidoacetate (M570, CsF11SO2N(CH3)CH2COO'); perfluorooctanesulfonamidoacetate (M556, CsF 11SO2N( CH)CH2COO-); pertluorooctanesulfonylamide (PFOSA, C8F17SO2NH2); perfluorooctanoate (PFOA, C7F13COO); and perfluorohexanesulfonate (PFHS C6F13SO3). Overall, the geometric mean measured concentration of PFOS was 34.9 ppb (95% CI 33.3-36.5). The measured PFOS concentration ranged from less than the lower limit of quantitation (LLOQ) of 4.1 ppb to 1656.0 ppb. The geometric mean for PFOS was significantly higher among males (37.8 ppb; 95% CI 35.5-40.3) than females (31.3 ppb; 95% CI 30.0-34.3). No significant difference was observed with age. Charlotte (NC) had the highest geometric mean serum PFOS concentration (51.5 ppb) and Boston (MA) the lowest (29.5 ppb). Bootstrap analyses were used to calculate a 95% tolerance limit for PFOS of 88.5 ppb with an upper 95% confidence limit of 100.0 ppb. Additional geometric mean and tolerance limit data are reported for PFOA, PFHS, PFOSAA and M570. The geometric mean and 95% tolerance limits of these fluorochemicals were, on average, an order of magnitude (or more) lower than PFOS. PFOS and PFOA were highly correlated (r = .63). PFOS had lower correlations with PFOSAA (r = .42), PFHS (r = .38) and M570 (r = .20). The number of samples with measured PFOSA and M556 concentrations below the LLOQ prohibited meaningful statistical analyses for these compounds. The findings from this analysis of serum PFOS concentrations are consistent with those previously reported. The human data, to date, suggests the approximate average serum concentration in non-occupational adult populations may be 30 to 40 ppb with 95% of a population's serum PFOS concentrations below 100 ppb. Since serum PFOS concentrations likely reflect cumulative human expo-sure, this information will be usefui for risk characterization. |
| Report Number | 8EHQ-0501-373C |
| Ntis Number | OTS000811844Q |
| Is Certified Translation | No |
| Dupe Override | No |
| Number Of Pages | 324 |
| Is Public | Yes |
| Language Text | English |