Dose–response curves for erythrocyte protoporphyrin vs blood lead: Effects of iron status
Marcus, AH; Schwartz, J
HERO ID
48329
Reference Type
Journal Article
Year
1987
Language
English
PMID
| HERO ID | 48329 |
|---|---|
| In Press | No |
| Year | 1987 |
| Title | Dose–response curves for erythrocyte protoporphyrin vs blood lead: Effects of iron status |
| Authors | Marcus, AH; Schwartz, J |
| Journal | Environmental Research |
| Volume | 44 |
| Issue | 2 |
| Page Numbers | 221-227 |
| Abstract | An increase in erythrocyte protoporphyrin (EP) is one of the most useful indicators of adverse biological response to lead exposure. A nonlinear mathematical model relating EP to blood lead concentration (PbB) was fitted to data in a sample of 1677 U.S. children (ages 2-6 years) in the Second National Health and Nutrition Examination Survey (NHANES II). Iron status was defined by percentage transferrin saturation (PTS). The dose-response curves for EP vs PbB increased systematically with decreasing PTS, largely due to decrease of a parameter proportional to red cell lead-holding capacity with decreasing PTS. |
| Doi | 10.1016/S0013-9351(87)80230-X |
| Pmid | 3691443 |
| Wosid | WOS:A1987L446100007 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |