The elevation of mouse thymus cell cyclic adenosine monophosphate (cAMP) by lipopolysaccharide
Tsien, WH; Sampson, M; Sheppard, H
| HERO ID | 4851240 |
|---|---|
| In Press | No |
| Year | 1981 |
| Title | The elevation of mouse thymus cell cyclic adenosine monophosphate (cAMP) by lipopolysaccharide |
| Authors | Tsien, WH; Sampson, M; Sheppard, H |
| Journal | Immunopharmacology |
| Volume | 3 |
| Issue | 3 |
| Page Numbers | 253-258 |
| Abstract | The ability of certain lipopolysaccharide (LPS) preparations to elevate cyclic adenosine monophosphate (cAMP) in mouse thymus cells in the presence of Ro 20-1724, 4-(3-butoxyl 4-methoxybenzyl)-2-imidazolidinone, was not related to the source of supply, bacterial strain, or method of extraction. Under the same conditions adenosine is a potent stimulator of thymus cell cAMP and is, of course, blocked by the further addition of theophylline. When theophylline was added to the LPS preparations with Ro 20-1724, the cAMP production was also blocked. These studies suggested that the observed stimulation of cAMP by LPS preparations was due to adenosine and/or its nucleotides present as contaminants. |
| Pmid | 6273361 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |