Radical C-H functionalization of heteroarenes under electrochemical control
O'Brien, AG; Maruyama, A; Inokuma, Y; Fujita, M; Baran, PS; Blackmond, DG
| HERO ID | 4854483 |
|---|---|
| In Press | No |
| Year | 2014 |
| Title | Radical C-H functionalization of heteroarenes under electrochemical control |
| Authors | O'Brien, AG; Maruyama, A; Inokuma, Y; Fujita, M; Baran, PS; Blackmond, DG |
| Journal | Angewandte Chemie (International Edition) |
| Volume | 53 |
| Issue | 44 |
| Page Numbers | 11868-11871 |
| Abstract | Electrochemical reactions are shown to be effective for the C-H functionalization of a number of heterocyclic substrates that are recalcitrant to conventional peroxide radical initiation conditions. Monitoring reaction progress under electrochemical conditions provides mechanistic insight into the C-H functionalization of a series of heterocycles of interest in medicinal chemistry. |
| Doi | 10.1002/anie.201407948 |
| Pmid | 25209429 |
| Wosid | WOS:000344050700027 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |