Reaction of Ethyl 4-Halo-3-oxobutanoate with Diethyl Malonate, Methyl Cyanoacetate, and Malononitrile
Kato, T; Kimura, H; Tanji, K
| HERO ID | 4932525 |
|---|---|
| In Press | No |
| Year | 1978 |
| Title | Reaction of Ethyl 4-Halo-3-oxobutanoate with Diethyl Malonate, Methyl Cyanoacetate, and Malononitrile |
| Authors | Kato, T; Kimura, H; Tanji, K |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 26 |
| Issue | 12 (1978) |
| Page Numbers | 3880 |
| Abstract | Ethyl 4-bromo (and chloro)-3-oxobutanoate (1 and 2) reacts with diethyl malonate in the presence of sodium hydride to give diethyl 5-ethoxycarbonyl-3-oxohexanedioate (3) and diethyl 5-carboxy-3-oxohexanedioate (4). Similarly, reaction of the haloester (1, 2) with methyl cyanoacetate gives 1-ethyl methyl 5-cyano-3-oxohexanedioate (6) and 1-ethyl hydrogen 5-cyano-3-oxohexanedioate (7). On the other hand, 1 reacts with malononitrile in the presence of triethylamine to give ethyl 5-amino-4-cyanofuran-2-acetate (8) and ethyl 3-amino-2, 4, 4-tricyano-2-cyclopenten-1-ylideneacetate (9). |
| Wosid | WOS:A1978GE77400040 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |