Tablets compressed with gastric floating pellets coated with acrylic resin for gastro retention and sustained release of famotidine: in-vitro and in-vivo study
Qi, X; Jiang, Y; Zhang, H; Wu, Z
| HERO ID | 4936774 |
|---|---|
| In Press | No |
| Year | 2015 |
| Title | Tablets compressed with gastric floating pellets coated with acrylic resin for gastro retention and sustained release of famotidine: in-vitro and in-vivo study |
| Authors | Qi, X; Jiang, Y; Zhang, H; Wu, Z |
| Journal | Journal of Pharmacy and Pharmacology |
| Volume | 67 |
| Issue | 4 |
| Page Numbers | 493-500 |
| Abstract | <strong>OBJECTIVES: </strong>The aim of this study was to prepare a disintegrating gastric floating tablet composed of floating pellets coated with acrylic resin to prolong the gastric residence time and increase the oral bioavailability of famotidine.<br /><br /><strong>METHODS: </strong>The gastric floating pellets containing famotidine, stearyl alcohol and microcrystalline cellulose (1 : 10 : 1) were prepared by extrusion-spheronization process and coated with acrylic resin, then compressed into tablets with Avicel PH 301 pellets and cross-linked polyvinylpyrrolidone. The coating weight, volume ratio of Eudragit RL30 D and RS30 D and solid content of coating fluid were optimized by Box-Behnken design.<br /><br /><strong>KEY FINDINGS: </strong>In 0.1 M HCl, tablets can immediately disintegrate into pellets which can remain floating and sustained drug releasing over 12 h. The AUC0-∞ of famotidine gastric floating pellets (7776.52 ± 1065.93 h ng/ml) administered into rats was significantly higher than that of marketed rapid release tablets Xingfading® (Xingyi, Shanghai, China) (4166.23 ± 312.43 h ng/ml), while the relative bioavailability was 187.01 ± 22.81%.<br /><br /><strong>CONCLUSIONS: </strong>The experimental results indicated that the optimized formulation did offer a new gastro retention and sustained release approach to enhance the oral absorption of famotidine. |
| Doi | 10.1111/jphp.12339 |
| Pmid | 25495700 |
| Wosid | WOS:000351832900003 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |