Localization of renal calcium transport; effect of calcium loads and of gluconate anion on water, sodium and potassium
Howard, PJ; Wilde, WS; Malvin, RL
HERO ID
4946704
Reference Type
Journal Article
Year
1959
Language
English
PMID
| HERO ID | 4946704 |
|---|---|
| In Press | No |
| Year | 1959 |
| Title | Localization of renal calcium transport; effect of calcium loads and of gluconate anion on water, sodium and potassium |
| Authors | Howard, PJ; Wilde, WS; Malvin, RL |
| Journal | American Journal of Physiology |
| Volume | 197 |
| Page Numbers | 337-341 |
| Abstract | We have performed a first series of experiments using our stop flow technique to localize renal transport of calcium in dogs. Calcium is found to be actively reabsorbed in a far distal area but does not appear to be actively lowered in concentration in proximally derived samples. In a second series of dogs, elevation of plasma calcium by infusion of the salt CaCl2 caused a 43% reduction in the additional volume of water reabsorbed by the proximal tubule during stop flow. Calcium does not interfere with the active reabsorption of sodium in the distal area and does not cause significant increases in sodium excretion. In contrast calcium causes a considerable increase in potassium secretion at a far distal site. When calcium gluconate was employed, severe impairment of distal sodium and calcium reabsorption occurred in addition to the increased potassium secretion. We suggest that the gluconate anion restricts the movement of sodium, calcium and potassium electrostatically thus obligating cations to remain in the tubular urine depending upon their reabsorption potential. |
| Doi | 10.1152/ajplegacy.1959.197.2.337 |
| Pmid | 14403462 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |